Alopecia areata, a non-scarring form of hair loss, can considerably impact quality of life. This study explores how demographic and clinical factors influence the quality of life for individuals living with this condition. Method: We conducted a cross-sectional study at Ziauddin Hospital, Karachi, Pakistan, to investigate the influence of demographic and clinical features on quality of life (QoL) in alopecia areata patients (n=150). We collected demographic and clinical data, assessed disease severity using the Severity of Alopecia Tool (SALT) score, and evaluated QoL with the Dermatology Life Quality Index (DLQI) for adults and the Child (CDLQI) for children. Multivariate logistic regression then analyzed the relationships between patient characteristics and QoL. Result: Among the 150 participants, the average SALT score indicated moderate alopecia areata severity (5.78 ± 0.95). The mean DLQI scores for mild and moderate cases of AA were 7.9 and 10.1 respectively and the difference was insignificant. AA had mostly moderate and small effects on the QoL of adult and pediatric patients 46.6% and 35.6% respectively Interestingly, gender emerged as a significant factor, with females reporting higher QoL impairment (higher DLQI scores) compared to males (p < 0.05). Furthermore, patients with no family history of AA experienced significantly lower QoL than those with a positive family history (p = 0.033). Conclusion: Our findings suggest that, beyond disease severity, the psychological burden of alopecia areata manifests differently based on gender and family history. This underscores the importance of considering these factors when designing treatment approaches and support systems to optimize quality of life for individuals with this condition.