The dissolution properties of a drug and its release from a dosage form have a basic impact on its bioavailability. Solving solubility problems is a major challenge for the pharmaceutical industry with developments of new pharmaceutical products. The aim of the present study was to increase the solubility of a poorly water soluble BCS class II drug, dipyridamole. Liquisolid Systems of Dipyridamole were prepared using Maisine CC, Avicel pH 102, Aerosil and Tween 80. And were prepared by hot melt granulation technique with Gelucire 48/16 and Polyox WSR N-80 which involved preparation of a homogenous dispersion. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow properties, and general quality control tests of tablets using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), The lower ratio of Drug: Liquid are showing good flow at a particular excipient ratio. This might be due to lower amount of liquid in the formulation due to which cohesive forces might be less. Polyox WSR N-80 showed better angle of repose values when compared to Gelucire. As Gelucire is a lipid-based excipient its granulation properties are less. All the formulations prepared by liquid solid compact showed almost entire drug release within 15 min. because of the drug being in solubilized state.where as in Melt granulation technique Polyox is a water swellable polymer due to this drug diffusion is lower whereas Gelucire is a water-soluble excipient. Based on the drug release MGF3 formulation showed better results.