1. TAUFIQ AHMAD - Department of Eastern Medicine, Government College University Faisalabad, Pakistan.
2. SULTAN AYAZ - Department of Eastern Medicine, Government College University Faisalabad, Pakistan.
3. ABID RASHID - Faculty of Medical Sciences, Government College University Faisalabad, Pakistan
4. HAFIZ MUHAMMAD ASIF - University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The
Islamia University of Bahawalpur, Pakistan.
5. SYED MUHAMMAD ALI SHAH - Department of Eastern Medicine, Government College University Faisalabad, Pakistan.
Herein we present the comparative study of the total phenolic and flavonoid contents of both individual as well as mixed herb extraction in hydroethanolic system. It is shown that PHE show remarkable TPC (12.50 mg RuE/g of herb extract) and TFC (58.52 mg GAE/g of herb extract) values at concentrations of 30 μg/mL while at similar concentrations the DPPH %inhibition was recorded to be as high as 90.18% compared to the 76.57 % of highest radical scavenging individual extract of CR. The docking studies also gave information about some of the best anti-convulsant discrete agents like CHR and RSM while other may also have synergistic effects like GER with Citral etc. These results showed that polyherbal extract can be used as an effective source of antioxidant and anti-epileptic drugs.
IN-SILICO EVALUATION OF OCIMUM SANCTUM, WITHANIA SOMNIFERA, VALERIAN OFFICINALIS AND CATHARANTHUS ROSEUS AS POSITIVE ALLOSTERIC MODULATORS OF GABAA RECEPTORS (AN INSIGHT TO ANTI-CONVULSANT EFFECTS)