Water pollution is a substantial threat to humans. Micropollutants like pharmaceuticals have been found in almost every source of drinking water. They are so persistent that even waste water treatment plants are incapable to remove them properly from waste water and ultimately their residues approaches the surface water through effluents. A current investigation focuses on bioremediation of selected pharmaceutical residues in drinking water using locally isolated fungal species. Five commonly found drugs such as ciprofloxacin, aspirin, ibuprofen, fenofibric acid and carbamazepine in drinking water (tap, tube well and hand pump) samples were analyzed and treated with Aspergillus niger as it was found as most resistant and active species for removal of pharmaceuticals. Degaradation rate of drugs were checked for 12 days under optimized conditions. The samples were taken after every 2 day and analyzed on HPLC. Disappearance of ipubrufen and carbamazepine was noted for maximum time i.e., 12 days while for aspirin degradation was observed till 8 days. pH of liquid media was found to be unstable during degradation of compounds and detected as acidic for all except carbamazepine. Further investigations are suggested for the determination of capabilities of fungal species regarding bioremediation of organic micropollutants.