Past studies have been conducted to examine the achievement of students and performance in developed countries, but only rare researches were addressed in developing countries like Pakistan. Pakistan is still lacking behind to conduct the research in the improvement Critical Thinking Skills (CTS) practices. In this study to determine interpretation and analysis based on 9 E learning and teaching model in statistics learning 12th grade students of CTS improvement. This research studies a descriptive by its nature. A total number of 110 student’s 12th grade (60 boys and 50 girls) statistics students were selected sample through stratified random sampling, and two colleges were selected with randomly sampling approach. The data was collected through questionnaire contained 5-point Likert scale. The two questionnaires (9 E learning and teaching instructional model and CTS interpretation, analysis) were developed for this study. 9 E learning and teaching instructional practices were an independent variable, whereas CTS namely interpretation, and analysis was a dependent variable. There were total 36 questions of 9 E learning and teaching instructional model and total 25 questions of interpretation and analysis of CTS. The students were taught with 9 E learning and teaching model based. The result of the study showed that there was strong and positive effect of 9 E learning and teaching instructional practices on students CTS of the interpretation and analysis at 12th grade students. The finding of the study has revealed that there were nine processes involved in the development of CTS among students during the interpretation and analysis. The study would be helpful for teachers and students, improvement in teaching and implementing new learning approaches with instructional learning and teaching. However, there are limited research studies carryout with the 9 E learning and teaching model with CTS of the statistics students. This study will be able to respond the interpretation and analysis, whether the effectiveness relationship 9 E learning and teaching model and CTS of statistics in Pakistan.