Transgenic plant vaccines or simply edible vaccines consist of genetically modified products obtained by incorporating the genes of interest into some plants encoding specific antigen causing the disease. Compared to previously existing traditional vaccines the edible vaccines offer several advantages as safe, cost-effective, easily administrable, storable etc. Oral administration of these vaccines stimulates both mucosal (IgA mediated) and systemic (IgG mediated) immunity and therefore provides an improved mean to fight against infectious diseases. In addition to that the plants aid in preserving the antigenic possessions of such vaccines even after subsequent ruin in intestine. Some plants that have been used as edible vaccines recently in some part of the world include corn, bananas, potatoes, tomatoes etc. Despite of such advantages over the traditional vaccines, there exist tremendous challenges in the successful production and broad implementation of these third-generation vaccines. However, it has been considered that, there are numerous risks throughout the manufacture and distribution phases of this acquaintance, with possible impression on the atmosphere and on human health. Incessant efforts are continuing in several parts of the world to fabricate effectual plant vaccines for many anthropological and animal associated diseases. This paper analyses the current conservative approaches as well as the progress exertions by scientists to recover the creation of plant-based vaccines. This article further highlights on the jeopardies allied with the invention and manufacturing of these vaccines and how they can be controlled through suitable governing actions at all phases of manufacturing and delivery.