The Universal Filtered Multicarrier (UFMC) is an emerging modulation waveform technique for nextgeneration wireless networks. The sub-band filtering operation may disrupt the orthogonality between the subcarriers, which causes inter-carrier interference (ICI) and inter sub-band interference (ISBI) (i.e., the quantity of interference on the neighboring sub-bands) and degrades the system performance. Thus, the sub-band filter design in UFMC based systems plays an important role in its performance. This paper analyzes the interference in the multi-service/user-based UFMC system with the closedform of the interference variance in terms of sub-band size and filter length. In addition, the sub-band filter configuration is adapted according to the sub-band size (i.e., number of subcarriers per sub-band) such that the system generates the minimum level of interference. With the proposed method, the overall signal to interference ratio improved by around 8 dB. Further, the transmission time interval (TTI) of the UFMC symbol could be reduced by shortening the symbol overhead (filter tail) and hence improving the frame efficiency.