Manuscript Title:

PREPARATION AND CHARACTERIZATION OF QUETIAPINE FUMARATE SUPERPOROUS HYDROGELS USING FACTORIAL DESIGN APPROACH

Author:

CHELIKANI RAM VENKATESH, GADELA VENKATA RADHA

DOI Number:

DOI:10.17605/OSF.IO/EZ6N3

Published : 2022-03-10

About the author(s)

1. CHELIKANI RAM VENKATESH - Department of Pharmaceutics, Gitam Institute of Pharmacy, Visakhapatnam, India.
2. GADELA VENKATA RADHA - Faculty of Pharmacy, Gitam Institute of Pharmacy, Visakhapatnam, India.

Full Text : PDF

Abstract

Objective: The purpose of this study is to develop and evaluate a gastroretentive drug delivery system based on a Superporous hydrogel using Quetiapine Fumarate and characterized for Mechanical strength, Porosity and Dissolution.

Method: Quetiapine Fumarate (QTP-F) based Superporous Hydrogels were prepared by using 3 2 factorial design to study the effect of independent variables on dependent variables. The selected independent variables considered were the concentration of HPMC K4M (g) (X1); HPMC K100M (g) (X2); and Stirring time (seconds) (X3). Mechanical strength, Porosity, and the Dissolution were selected as the dependent variables.


Keywords

Quetiapine Fumarate, 3 2 factorial design, Mechanical strength, Porosity and Stirring time.