Many diseases, including bacterial, viral, and cancerous infections, are linked to blood group. Previous reports display the relationship between the susceptibility of patients to coronavirus disease 2019 and blood group A. In the present study, we investigated the relationship of blood groups and Rh phenotypes with susceptibility to coronavirus disease 2019 infection, severity of disease, recovery period, and mortality of patients in Taif City, west Saudi Arabia. Patients were enrolled from March 2020 to October 2021. A total of 722 real-time PCR (PR-PCR) confirmed coronavirus disease 2019 (COVID-19) in King Faisal Hospital in Taif City. Data was analyzed using the Chi-squared test (χ2) to evaluate the association of blood groups. The out-finding data indicated that blood types A, B, and Rh+ are more susceptible to infection with SARSCoV-2 and may develop severe COVID-19 symptoms, while blood types O and Rh are at a lower risk of COVID-19 infection, to an extent. And people with blood type B+ are more likely to die. Finally, out data was confirmed suggesting blood group may play a role in COVID-19 Susceptibility and mortality.