Manuscript Title:

SUPERPOROUS HYDROGEL BASED FLOATING MINI TABLETS OF TELMISARTAN: INNOVATIVE APPROACH FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM

Author:

A. SUSEENDHARNATH, Dr. MOHD. JAVED NAIM

DOI Number:

DOI:10.17605/OSF.IO/O/QMC3N

Published : 2022-03-10

About the author(s)

1. A. SUSEENDHARNATH - Research Scholar, Bhagwant University, Ajmer, Rajasthan, INDIA-305004.
2. Dr. MOHD. JAVED NAIM - faculty of Pharmacy, Bhagwant University, Ajmer, Rajasthan, INDIA-305004

Full Text : PDF

Abstract

The present study was carried out with an objective of preparation and in vitro evaluation of Superporous hydrogels based floating mini-tablets of telmisartan to improve its bioavailability. Superporous hydrogels were prepared by using Chitosan, Ac-Di-Sol and various other polymers and evaluated for density, porosity and mechanical strength. The dried SPH were compressed into 5mm Minitablet and filled into size ‘2’ capsule. Capsules were evaluated for dissolution studies THT2 is selected as the optimized formulation as it sustained drug release and more than 85% of drug in 12 hours at a lower concentration of polymer. Preformulation studies for drug excipient compatibility is done by FTIR spectroscopy it was observed that there was no compatibility problem with they are used in study. DSC studies also prove that there were no critical collaborations between the drug and polymers. There are no significant changes found in the stability studies


Keywords

Telmisartan, Chitosan, Ac-Di-Sol, mini-tablet, THT2, DSC, Capsule ‘2’.