Anti-cancer and Corona medications can be examined and improved by Cheminformatics which is a mix of chemistry, computer, and mathematics. Cheminformatics includes graph theory and its instruments. Any number that can be extraordinarily determined by a graph is known as a graph invariant. In chemical graph theory, chemical compounds are changed over into graphs with atoms as vertex and bonds as edges. Numerous topological lists have been produced for the assurance of actual properties of chemical structures of compounds. The review figured recently pre-arranged topological invariants, K-Banhatti Sombor Invariants, Dharwad Invariants, Quadratic-Contra harmonic Invariants and Irregularity Sombor Index of chemical structures utilized in crown medication to investigate their qualities, for example, hyaluronic corrosive. The determined outcomes are important and supportive in understanding the profound physical and chemical way of behaving of these chemical structures in the human body. These outcomes will likewise be helpful for analysts to understand how these chemical structures can be developed, and improved with various physical, and chemical properties and the viability of corona disease.