The use of frankincense for therapeutic purposes continues from ancient times till now. The traditional uses have given us vital information for its bioactivity. However, modern medicine needs to obtain scientific evidences to establish its uses. In our research, we have investigated and evaluated the degree of alteration which caused by exposing the white albino rat of Wistar strain to treatment of frankincense aqueous extract. The evaluation took place through two types of examinations in addition to measuring body weight; the first one was the biochemical examination and the second was the histological examination. The biochemical examination has been done through assessment of function tests of kidney and liver. The function tests for the liver show elevation of ALP in frankincense treated group, while bilirubin, AST and ALT levels were decreased. The biochemical assessment of the kidney reveals that there is an elevation of the serum urea level in the treated group on the contrary serum creatinine and uric acid which appeared slightly decreased. The histological examination has been completed using hematoxylin and eosin staining. The results stated that there is a disarrangement of hepatic strands, mild hepatocellular necrosis, dilation and congestion of blood vessels with mild hemorrhage in liver while the histological examination of kidney revealed degeneration and necrosis of glomeruli structure. Concerning body weight of wistar rats, there was a significant increase in body weight of the wistar rats treated by frankincense aqueous extract.