This study examined the level of effectiveness of primary healthcare services in Cross River State (CRS). The data generated were analyzed using the t-test of mean difference and the confidence interval analysis. The results showed that there was a disparity in access to healthcare services between the Northern and Central senatorial districts, while there was no disparity in the level of accessibility to healthcare services between the Northern and Southern and the Central and Southern districts. There was no disparity in the level of government funding and management of healthcare services between the three senatorial districts, but there was a disparity in the level of infrastructural amenities distributed among the three senatorial districts. The government should increase its budgetary allocation for healthcare in line with the World Health Organisation’s 15 per cent of the total budget benchmark to boost the effectiveness of primary healthcare services, among others was recommended.