Background: Substance abuse, or drug misuse, is currently seen as a pervasive global issue and a detrimental affliction upon humanity. Adolescence is a critical phase of human development, characterized by significant physical and mental changes, and has a high likelihood of engaging in substance abuse. Objective: To determine the correlation between the knowledge and practices regarding substance use disorders its management and prevention among nursing students. Materials and Methods: In order to determine the objective of the study a cross-sectional study was carried out among 180 nursing students using convenient sampling at the selected setting. The study was carried out in the February Month, 2023. Data collection was done by self-administered questionnaire method using knowledge questionnaire and practices questionnaire. Results: there is a moderate positive co-relationship, found between knowledge and practices ‘r’ value is 0.64 and it was statistically significant (p<0.05). Hence researcher failed to accept the null hypothesis (H01). Conclusion: The health education plan aimed at students regarding drug usage has the potential to assist them in preserving their individuality and achieving optimal physical and mental well-being.