Many medicinal herbs are used to treat some disease in Indonesia. Ginger is one of the most widely used herbs that contains several bioactive constituents and possesses health promoting properties. Nagi Camphor comes from the family of Compositae. The plant is strongly aromatic. Both Nagi Camphor and ginger are used in traditional medicine to treat various diseases like hypertension and diarrhea. The objective of this study to investigate whether Ginger and Nagi Camphor methanolic extracts have the ability to decrease atrium contractility which, in turn, decrease cardiac contraction improving this effect may lead to use both herbs to treat hypertension. The isolated atrium of guinea pig was put in the organ bath containing Kerb’s solution aerated with Carbogen. Six doses of Methanolic extract of the Ginger and five doses of methanolic extract of Nagi Camphor were examined. Nor-epinephrine (10¯⁴ M) was injected to the organ bath as a pre-contraction for atrium contractility. Atrium relaxation was recorded using Powerlab kit which was connected to isometric transducer (in vitro study). The result indicated that all concentrations of Nagi Camphor and Ginger reduced the atrium contraction significantly (p<0.05). The herbs also reduced the contractlity of the heart and these herbs maybe used to reduced hypertension.