Beam-slab, flat plate, and flat slab systems are commonly used structural systems. Reinforced concrete multistory buildings with large spans can reduce the number of columns needed to support the building, which can reduce cost and increase the useable space. Structural failures due to seismic tremors in densely inhabited areas have led to improvements in seismic codes with the objective of improving seismic performance. The seismic resistance offered by a structure is primarily attributed to the combination of its elastic strength, damping capabilities, and inelastic deformability. Buildings with smaller translational natural periods attract higher design seismic force coefficients The inertial forces develop at each floor owing to floor accelerations, which can lead to damage to the floor and other floor components. Notably, increasing the stiffness of buildings has a counterproductive effect on reducing drift, as higher stiffness leads to greater floor acceleration This paper compares the seismic performance of four different structural systems in a medium-rise reinforced concrete building with a fixed base. The four selected structural forms for a fixed-base reinforced concrete building are subjected to a set of selected earthquakes and analyzed using nonlinear time history analysis to study the seismic response parameters, such as the time period, base shear, peak roof displacement, and peak roof acceleration, for soil type hard in seismic zone v as per BIS code 1893-2016(Part 1).