Currently, Vietnam is entering the post-COVID-19 era. If before COVID-19, e-commerce was still a foreign concept to consumers, then in the post-COVID-19 era it has become popular and familiar to people. Thus, businesses are forced to completely change the way they approach customers, analyze needs, market, sell, and provide customer service. A question that arises is how businesses can reach their target customers and adjust their marketing methods to suit the post-COVID-19 market context. In this context, e-commerce businesses have many opportunities to apply a variety of methods that utilize information technology and digital marketing activities to "touch" the buying habits of consumers. Drawing on these methods, this article analyzes and predicts the application of advantages as well as recognizes the importance of e-commerce in the post-COVID-19 era. Through this, the authors propose solutions to improve the efficiency of e-commerce activities in Vietnam in the current period.