Decreasing soil fertility and organic matter are among the main factors affecting agricultural productivity particularly in semi-arid and arid areas. Different types of organic materials or waste can be turned into compost, and this composted organic material has substantial potential to enhance the soil fertility and organic matter. Hence, it is crucial to explore the role of locally sourced organic materials which are environmentally safe, inexpensive and perhaps an effective way of maintaining the soil fertility and improving of crops productivity. Currently a pot experiment was conducted to assess the influence of various organic fertilizers on sorghum growth, nutrients uptake and soil chemical properties. Seven different organic fertilizers such as vermicompost, haryali khaad, bio gold, nutri compost, farmyard manure (FYM), parthenium compost and plant fert compost including control during 2015. Sorghum was planted as a test crop in pots. Results indicated that use of organic fertilizers considerably enhanced the growth and dry matter of sorghum plants. However, parthenium compost showed better outcomes as compared to other organic fertilizers. Parthenium compost increased the chlorophyll content of sorghum and resulted in higher plant height, dry matter, leaf area index followed by vermicompost and plant fert compost. Likewise, sorghum plants showed higher uptake of nutrients such as nitrogen, phosphorus and potassium in their shoot and root after application of parthenium compost followed by vermicompost. Parthenium compost also increased the soil mineral N, P and K content while other organic fertilizer showed non-significant difference when compared with control. Soil showed slight reduction in pH and electrical conductivity (EC) after application of parthenium compost than other organic fertilizers. However other organic fertilizers increased ammonia emission during decomposition in pots as compared to control treatment followed by Parthenium compost. Hence the use of parthenium compost for improving crop efficiency and recycle the nutrients and accomplishing sustainable agriculture is highly encouraging.