Spirulina platensis is a good candidate as an in-feed antibiotics substitute for broilers. However, its use seems impractical owing to its high price, especially when being administered throughout the whole rearing period. Spirulina platensis is a good candidate as an in-feed antibiotics substitute for broilers. However, its use seems impractical owing to its high price, especially when being administered throughout the whole rearing period. The prohibition of feed grade antibiotic growth promoters and rising demand for sustainable protein sources have necessitated the exploration of new feed ingredients that offer a safe and nutritious alternative for poultry. This study aimed to assess the impact of dietary supplementation with spirulina on the performance, hematological parameters, and serum profiles of broiler chickens. Four hundred 1-d-old Broiler chicks were randomly assigned to 1 of 4 dietary treatments, consisting of 2 replicates of 50 birds each. Commercial mash starter and finisher diets were supplemented with 0.5%, 1%, and 1.5% of Spirulina platensis. The Body Weights, Feed Conversion Rate, Villi length, Carcass yield percentage were significantly increased by the dietary inclusion of the 1% of Spirulina platensis as compared to the control fed broilers. In conclusion, 1% of Spirulina platensis supplementation significantly increased Body weight, decreased Feed Consumption Ratios and increases the villi height. The Spirulina platensis offers a good alternative to improve poultry production.