Background: Restless legs syndrome (RLS) is a condition that causes a very strong urge to move the legs. The urge to move usually is caused by an uncomfortable feeling in the legs. It typically happens in the evening or at night when sitting or lying down. Moving eases the discomfort for a short time. It is commonly known to cause morbidity in patients on hemodialysis, making them prone to chronic mental health illnesses such as depression and anxiety, and also adversely impact their life. Non-pharmacological treatment of this syndrome involve using reflexology, cool dialysate, massage therapy and vibration therapy to alleviate this condition. Aim: to investigate the effect of vibration versus massage therapy on restless leg syndrome severity among patients on hemodialysis. Design: Quasi-experimental (pre/post) design was used. Sample: Purposive sample of 60 adult patients were divided randomly into vibration therapy group and massage therapy group; 30 patients /group were enrolled in the current study. Setting: The current study was carried out at the hemodialysis unit in one of Cairo university affiliated hospital, Egypt. Tools: Two tools were utilized for data collection; Tool I: Personal and Medical Background Information Form, Tool II: The International Restless Legs Syndrome Study Group Rating Scale (IRLS). Results: The mean age among vibration therapy group and massage therapy group were (47.3±12.7), (50.1±14.2) respectively. 60 % of both groups were females. There was a highly statistically significant difference in the total mean scores of restless leg syndrome severity scores among the pre-intervention, two weeks and four weeks after intervention phases in both vibration and massage therapy groups (P = 0.00*). Conclusion: There was highly statistically significant difference in the total mean scores of the restless leg syndrome severity scores between massage therapy and vibration therapy groups after four weeks of intervention so, the study concluded that, both vibration and massage therapy were effective in reducing RLS severity, while massage therapy was more effective. Recommendation: vibration and massage therapy should be added as a possible non- pharmacological intervention in managing restless leg syndrome.