Manuscript Title:

DENTAL PULP RESPONSE TO EPIGALLOCATECHIN GALLATE AS A VITAL PULPOTOMY AGENT

Author:

SHAIMAA MOHAMED MAHFOUZ OMER, RANDA HAMED MOUSTAFA EL-SHERBINY, REHAM MOHAMED ALI ABDEL LATIF

DOI Number:

DOI:10.5281/zenodo.12798170

Published : 2024-07-23

About the author(s)

1. SHAIMAA MOHAMED MAHFOUZ OMER - Department of Paediatric Dentistry, Preventive Dentistry and Dental Public Health, Faculty of Dentistry, Suez University, Suez, Egypt.
2. RANDA HAMED MOUSTAFA EL-SHERBINY - Department of Oral Pathology, Faculty of Dentistry, Suez University, Suez, Egypt.
3. REHAM MOHAMED ALI ABDEL LATIF - Department of Paediatric Dentistry, Preventive Dentistry and Dental Public Health, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.

Full Text : PDF

Abstract

Background: A conservative procedure called a pulpotomy is used to keep decaying primary teeth in place until permanent teeth develop. The main polyphenol found in green tea, epigallocatechin gallate (EGCG), has several health benefits, including being an antioxidant, inflammatory reducer, antiseptic, and antibacterial. The objective of the present investigation was to histopathologically analyze and compare the dental pulp responses of dogs to EGCG and 15 concentration of Buckley's formula of FC as essential pulpotomy medicines. Methods: Two healthy Mongrel dogs' teeth were randomly selected for the experimental split-mouth study. EGCG and FC were used as vital pulpotomy agents. The treated teeth were assessed at four and nine weeks, and the pulp tissues were checked for fibrosis, inflammation, and other histological alterations. In addition to using an "independent samples t-test" to compare the means of two treated groups, a Paired t-test was performed to compare the means of the same group over two-time intervals. Results: When comparing the EGCG group at 4 weeks of treatment to the FC group, there was a noticeable reduction in pulp inflammation, vasodilation, and necrosis. After nine weeks of treatment, the FC group showed more destruction of the odontoblastic layer than the EGCG group, as well as substantial increase in fibrosis and necrosis. Conclusion: With respect to the study's limitations, the histological evaluation of the experimental animal model demonstrated that EGCG was more effective than FC as a pulp capping medication for vital pulpotomy.


Keywords

Green Tea, Pulpotomy, Epigallocatechin Gallate, Formocresol.