In todays world, pursuing food security and expanding food availability are critical aspirations for countries of varying economic statuses. The agricultural sector plays a vital role in addressing these challenges, and researchers have introduced a modern approach utilizing LED technology to enhance plant growth and metabolic processes in a controlled environment. However, the lack of light intensity and limited spectrum can negatively impact our plants. To overcome this, scientists have developed an innovative solution that uses LED technology to improve plant growth and metabolic processes. A recent study delved into the effects of different light spectrums, including white, UV, red, far red, red/blue, blue, and green, on physiological parameters, bioactive materials, and nutritional composition in various lettuce cultivars. While previous research has focused on growth, quality, and bioactivity, it is essential to investigate the nutritional content of these cultivars as interest in our food's nutritional value grows. By examining the nutritional content of hydroponically grown lettuce cultivars, we can make strides toward a more sustainable and healthier future.