Background: The use of artificial intelligence (AI) in healthcare has been one of the processes that guide and influence the management of the healthcare processes. The actualization of the healthcare processes comes with the management of the requirements for sustaining the management of quality. The quality factor would have implications on the generation and actualization of the healthcare processes. Objective: The objective of the review was to appreciate the role of AI in improving the healthcare quality in Saudi Arabia. The review focused on the current use of AI, the role of AI and the best practices to help increase of AI to improve the healthcare quality. Methodology: The research used a systematic review, which focused on the evaluation of the medical literature relating to the use of the AI and the application on healthcare quality. The use of the JBI and PRISMA tools helped in the analysis, which played a critical role in promoting the actualization of the healthcare quality processes. The inclusion and exclusion criteria were implemented using the PRISMA flowchart, which resulted in the selection of 12 publications. Results: The application of the inclusion and exclusion criteria led to the identification of 12 articles that helped on the study of the use of AI in addressing healthcare quality. The main themes came in the role of AI in improving decisions making and actualizing the needs for sustaining the healthcare development needs. The main findings indicated that the use of the AI processes has an impact in improving the healthcare quality, through influencing decisions, their impacts and timeliness in addressing healthcare issues. The main issues came in the lack of commitments and procedures for sustaining the AI systems in Saudi’s healthcare systems. Conclusion: The conclusions from the review indicated that the use of AI could help improve the healthcare quality, through improving decisions making and enabling an effective process for addressing the healthcare requirements. The recommendations included the identification of the research on the processes for AI implementation to help address the healthcare quality processes.