Background: Varicose veins disease is a prevalent vascular condition characterized by abnormally dilated, twisted, and elongated veins that cause discomfort, pain, swelling, thrombosis, bleeding, ulcerations and disability that has negative impact on patient′s quality of life. Aim: to evaluate the effect of Buerger- Allen Exercise on health-related quality of life among patients with varicose veins. Design: Quasi-experimental pre- posttest nonequivalent control group design was utilized. Setting: This study was conducted in the outpatient clinic of vascular department at Al Kasr El Aini hospital which affiliated to Cairo University Hospital, Egypt. Sample: a convenient sample of 66 adult male and female patients with confirmed diagnosis of varicose veins selected for a period of six consecutive months and divided into study and control groups. Tools: data was collected using Personal and Medical Background Information Form (PMBIF), CEAP Clinical Classification, The Aberdeen Varicose Veins Questionnaire (AVVQ) and Observational checklist of Buerger- Allen Exercise. Results: The study findings revealed that there were significant statistical differences of varicose veins quality of life score between study and control groups after application of Buerger- Allen Exercise. Conclusion and recommendation: Buerger Allen exercises was effective in improving varicose veins patient′s quality of life by enhancing circulation, alleviating symptoms and preventing further complication; hence, it is highly recommended to be part of therapeutic regimen of patients with varicose veins.