The swift adoption of Artificial Intelligence (AI) in the healthcare system is transforming the nature and provision of the nursing practice. Nurses are in the middle of this shift as hospitals are implementing more advanced digital solutions, where AI-driven systems are used to improve the process of patient assessment, monitoring, and clinical decision-making (Smith, 2022). The use of AI in the workflow, including predictive analytics, automated documentation, and intelligent monitoring devices, is enhancing the efficiency of the workflow, as well as providing assistance in the early detection of patient deterioration, which positively affects safer and more precise care delivery (Lee and Yusuf, 2023). Irrespective of all these advantages, there are various risks associated with the use of AI, such as ethical issues, bias in the algorithm, loss of privacy of data, and the possibility of over-dependence on automated systems. Moreover, the lack of digital literacy is noted by many nurses, which also points to the necessity to provide thorough training and establish strict rules. The paper will look at the present uses of AI in the nursing practice, opportunities, challenges, and future directions of AI use in nursing practices. It also offers evidence-based guidance to make sure that AI is introduced safely, ethically, and in a manner that enhances and not obsolesces the critical thinking and caring that constitute the nursing profession.