Organizations operating across multiple industries face distinctive profitability challenges arising fundamentally different cost structures, margin behaviors, and operational dynamics. Manufacturing activities typically emphasize asset intensity, capacity utilization, and cost absorption, while trade-oriented operations prioritize speed, working capital efficiency, and margin optimization. Managing profitability across these contrasting models requires executive-level strategies that move beyond function-specific or industry-specific approaches. This article examines profitability management as a strategic business management capability in multi-industry organizations spanning manufacturing and trade. It argues that traditional profitability frameworks, often developed for single-industry contexts, fail to capture the structural complexity and decision trade-offs inherent in multi-industry operations. Drawing on business management theory and executive practice, the study develops an integrated profitability management framework that aligns cost structures, pricing strategies, volume decisions, and performance measurement across industries. The proposed framework emphasizes executive decision-making, cross-industry performance visibility, and integrated control mechanisms as essential enablers of sustainable profitability. By comparing and synthesizing profitability drivers in manufacturing and trade, the article highlights how executives can manage trade-offs between scale, margin quality, risk exposure, and long-term value creation. The study contributes to the business management literature by offering an original strategic perspective on how senior leaders can design coherent profitability strategies across diverse operational models.