Background:Self-marketing in the workplace plays a crucial role in all fields, especially in the nursing sector. Therefore, self-marketing programs have a significant effect on the ability of nurse interns to improve their public image, self-esteem, and promotion at work. This study aimed to identify the effects of a self-marketing skills training program on nurse interns' self-esteem. Methods: A quasi-experimental research design with a one-group pretest-posttest was used in this study at Ain Shams University Hospitals in Cairo Governorate, Egypt. The participants in the study included 160 nurse interns for participated in a self-marketing training program. Data collection involved instruments such as the Knowledge Questionnaire, the Intern Nurse Students Self-Marketing Skills Questionnaire, and the Self-Esteem Assessment Scale. Data entry and statistical analyses were conducted via SPSS version 26.0. Results: There were highly significant statistical positive correlations between nurse interns’ total self-marketing and total self-esteem with (R=0.794, P=0.00). Also, there was a highly significant positive correlation between nurse interns’ knowledge and self-marketing. Additionally, there were highly significant positive correlations between nurse interns’ knowledge, total self-marketing, and self-esteem at preintervention. Conclusion: The self-marketing training program significantly improved the knowledge and perceptions of nurse interns' self-marketing and improved their self-esteem. Based on these findings recommended that innovative teaching methods aimed at enhancing students’ self-marketing abilities should be created. Collaborative committees that include student members to generate ideas and formulate strategies for improving self marketing skills should be established.