Safety-critical industries such as chemicals, pharmaceuticals, energy production, and advanced manufacturing rely heavily on the controlled handling and transportation of hazardous materials. Failures in managing these materials can lead to severe consequences including industrial accidents, environmental damage, regulatory sanctions, and reputational loss. As industrial operations expand across complex organizational structures and global supply networks, the governance of hazardous materials has become an increasingly significant managerial challenge. Traditional compliance-based safety systems, while essential, often focus on procedural adherence rather than enterprise-wide leadership and coordination. This study examines the role of operational leadership in managing hazardous material risks within safety-critical industries. The paper argues that effective hazardous material control requires integrated managerial systems that extend across the entire organization rather than remaining confined to specialized compliance units. Through conceptual analysis of leadership theory, industrial risk governance, and enterprise management systems, the study develops the Enterprise Hazardous Control Leadership Model (EHCLM). The model explains how operational leadership can coordinate risk intelligence, compliance systems, and organizational accountability to create robust enterprise-wide hazardous material governance. The findings suggest that organizations adopting leadership-driven governance systems are better equipped to manage hazardous material risks across complex operational environments. By embedding risk management within operational leadership structures, firms can enhance safety performance, strengthen regulatory compliance, and improve organizational resilience in safety-critical industrial sectors.