Background: integrating vein visualization technology into oncology nursing practice contributes to improved clinical outcomes, including reduced pain, reduced anxiety level and higher successful insertion rates among chemotherapy patients. Aim: To evaluate the effect of using vein visualization device on (pain, anxiety, cannulation success rate) among patients receiving chemotherapy. Design: Quasi-experimental after -only nonequivalent control group design was utilized. Sample: A convenience sample of 60 adult male and female patients receiving chemotherapy for a period of six consecutive months, 30 in each group. Tools: the following tools were utilized in the current study: 1.Demographic and Medical Data Form (DMDF), 2. Adult Difficult Intra Venous Access (A-DIVA), 3. Numerical Rating Scale (NRS-11), 4. State Anxiety Inventory (SAI), 5. Success Rate Assessment Tool and 6. Vein Visualization Device (Pigeon Medical DVA30). Results: All participants in both groups received a 22-gauge cannula inserted in the hand (100%). 83.3% in the control group and 90.0% in the study group had severe insertion difficulty, there was highly statistically significant differences between the control and study groups regarding PVC insertion (pain, anxiety, and cannulation success rate) (p < 0.001). (83.3%) of the study group and 16.7% of the control group had successful insertion from the first attempt. Moreover, 80.0% of the control group need visualization time of 10–15 seconds, there was a highly statistically significant differences between both groups in pain scores as well complications during PVC insertion (p < 0.001; p< 0.002 respectively), , there was no statistically significant difference between the control and study groups regarding anxiety scores during PVC insertion (p > 0.05). Conclusion: vein visualization devices in PIVC insertion for chemotherapy patients is an effective intervention that significantly reduces pain, improves insertion success rates, but had no effect on anxiety levels. Recommendation: Future research with larger sample sizes should explore the integration of vein visualization devices within broader vascular access management programs in oncology practice.