Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by fluctuating symptoms that significantly affect patients’ daily functioning and quality of life. Pain and poor sleep quality are among the most prevalent and debilitating manifestations. With the growing integration of digital health technologies, mobile-based nursing instructions have emerged as a promising approach to support continuous patient education and self-management. Aim: To evaluate the effect of mobile-based nursing instructions on pain and sleep quality among patients with systemic lupus erythematosus. Design: pretest-posttest nonequivalent control group design was utilized. Research hypotheses: H1: The post total mean scores of pain intensity of patients with SLE who receive mobile based nursing instructions will be different than those who receive the routine hospital care. H2: The post total mean scores of sleep quality of patients with SLE who receive mobile based nursing instructions will be different than those who receive the routine hospital care. Setting: The current study was conducted at the Rheumatology and Rehabilitation Department at the outpatient clinics at Kaser Al-Ainy hospital, affiliated to Cairo University. Sample: A convenient sample of 100 Egyptian adult conscious women with a confirmed diagnosis of SLE within the last three years were included in the study along seven consecutive months. Tools: three tools were utilized; Demographic and Medical Data Form (DMDF), Numerical Pain Rating Scale (NPRS) and Sleep Quality Scale (SQS). Results: The study results revealed that there is a statistically significant improvement over time in pain intensity and sleep quality (p < .001), particularly at the eight-week follow-up among the study group. Conclusion: Mobile-based nursing instructions are an effective, accessible and patient-centered approach for improving pain and sleep quality among patients with SLE. Recommendations: Incorporating mobile-based educational tools into standard nursing care for patient with SLE, training nurses in digital health practices and conducting future research with larger samples to generalize the study findings.