Background: healthcare organizations use a variety of quality strategies to reduce costs and improve quality while increasing effectiveness to be competitive in the healthcare market. Lean management is one quality improvement method that focuses on the customer Aim: to examine the impact of lean management educational program for nurses on waste reduction during work. Methods: A quasi-experimental design with one group pretest-posttest was utilized to achieve the aim of the current study this study was conducted at King Khalid Hospital, Najran Saudi Arabia ,on a convenient sample of all nurses who are working in the previously mentioned setting and their number were (50).Three tools were utilized as follows:(1) Personal data sheet which includes personal data about nurses, (2) Knowledge questionnaire about lean management (241items). And (3) Wastes Identification Practices Observational Checklist (42 items). Results: There were statistically significant increase in staff nurses’ total knowledge of lean management mean scores (F=42.07, P=0.000) immediately post-training and three months later than pre-program as well as statistically significant differences in all dimensions of waste reduction practices mean scores (F=819.165, P=0.000*) immediately post-program and three months later than pre-program. Also, the current study findings revealed there was statistically significant negative correlation between nurses’ lean management knowledge and their waste reduction respectively (r=0.88, P=0.000). Conclusion: The educational program had positive effects for lean management of nurses on waste reduction during work. Recommendations: Implement mandatory educational and training programs about lean management for nursing staff to raising their awareness regarding application of lean methods.