Background: Agile leadership is a leadership approach that adapts to changing circumstances, promotes employee empowerment, and enhances an organization's ability to respond effectively to dynamic and unpredictable work environments. Aim: to explore agile leadership competencies from the perspective of nurse managers. Methods: descriptive exploratory design used in current study; this study was conducted at Al Moneira pediatric university hospital affiliated to Cairo University, Egypt; on a convenient sample of nurse managers their numbers (31 nurse managers). Three tools were utilized, namely :(1) Personal data sheet, (2) agile leadership knowledge questionnaire and (3) agile leadership practices observational check list. Results: most participants had low level in total agile leadership knowledge scores as (61.3%) and the majority of the participants had low level in total agile leadership practices as (96.8%). Conclusion: there was no statistical correlation between nurse managers’ knowledge and practices. Recommendations: training program should be conducted for nurse managers to enhance their knowledge and practices related to agile leadership.