Background: Nursing scheduling is a critical management function in 24-hour healthcare services because it influences workload distribution, perceived fairness, staff well-being, and patient safety. Manual scheduling is often time-consuming, prone to errors, and may limit transparency and staff participation. This study was conducted to assess the effect of designing and implementing an electronic scheduling system on staff nurses’ satisfaction with scheduling and patient safety culture. Methods: A quasi-experimental prepost study was conducted among 95 staff nurses working in surgical wards at Main Mansoura University Hospital, Egypt. The intervention involved designing and implementing an electronic scheduling system for duty rosters, shift requests, schedule changes, leave requests, and schedule visibility. Data were collected before implementation and three months after implementation using a structured scheduling satisfaction questionnaire and the Hospital Survey on Patient Safety Culture. Descriptive statistics, paired tests, chisquare tests, effect sizes, and Pearson correlation analysis were used. Results:A total of 95 nurses participated. Statistically significant improvements were observed across all scheduling satisfaction dimensions after implementation (p<0.001). The total satisfaction score increased from 59.15 ± 3.46 to 106.34 ± 8.10, with a 47.19-point improvement (t = -48.85, p<0.001, Cohen’s d = 7.58). Safety culture also improved across all composites. The overall positive response rate increased from 15.7% before implementation to 50.3% three months after implementation, representing a 34.6 percentage-point gain (p<0.001, Cohen’s d = 4.36). Post-implementation satisfaction was strongly and positively correlated with safety culture (r = 0.742, p<0.001). Conclusions: Designing and implementing an electronic scheduling system substantially improved staff nurses’ satisfaction and contributed positively to patient safety culture. Electronic scheduling may support nursing management by enhancing transparency, communication, perceived fairness, and workload organization. Further controlled, multicenter, and longer follow-up studies are recommended to confirm the sustainability and generalizability of these effects.