Religious Tolerance means accept and respect other’s religious opinion, allow religious believes, facilitate each other, mutual respect among all religious believers which is called religious freedom. Local wisdom is known as indigenous or local knowledge which is the basis of cultural identity. The purpose of this study has to find religious tolerance and local wisdom values maintaining harmonious and peaceful relation in South Sulawesi province. Study method was qualitative descriptive approach. Primary and secondary data were used to find the proper result. Primary data were collected by in-depth interviews with respective religious and society leaders. Secondary data were collected from documents, books, article, website and other related areas. The findings of this research were that South Sulawesi people’s daily life so much influenced by religion and local knowledge, these two values keeping harmonious and peaceful relation among different religion and different tribes.