Isenthalpic expansion is one of the major source of irreversibility in a typical split air conditioners (SAC). This paper presents the design analysis and experimental results of an ejector split air conditioner (ESAC). An ejector is employed in the SAC instead of a standard expansion device to recover expansion losses while improving cooling capacity and minimizing energy usage. A 5.2 kW nominal capacity SAC that was originally designed for HCFC-22 was used for performance testing. Initially, a baseline performance test was conducted in a psychrometric test chamber as per Indian standard IS 1391 part 1. The COP of the original SAC using HCFC-22 was 3.2, while the COP of modified ejector split air conditioner (ESAC) was increased by 28.12 % and found to be 4.1. With drop-in test, HC290 gave the COP of 4.6 which is 43.75 % higher compared to original SAC. Thus, use of HC-290 is an energy efficient and climate friendly alternative to HCFC-22 in Ejector split air conditioner.